Unravelling the mystery of cancer-associated fibroblasts (CAFs) populations in the tumor microenvironment by fully automated sequential chromogenic multiplex assay

Brightplex CAF 1

What's in the poster?

This poster was presented at the American Association for Cancer Research (AACR) virtual conference in 2020. This work will provide:

  • a background on the biology of cancer-associated fibroblasts (CAFs) in the context of tumor immunology and specifically in pancreatic ductal adenocarcinoma (PDAC)
  • a showcase of the Brightplex® CAF multiplex IHC panel comprised of alpha-SMA, FAP, PDGFR alpha, PDGFR beta, and S100A4
  • strategies for data acquisition, spatial and computational analysis, and digital pathology analysis of the organization of CAFs in tissue

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